We report a case of an acute ST-segment elevation myocardial infarction in a affected person with traditional cardiac risk factors using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient also had polycythemia, doubtless secondary to high-dose testosterone. The affected person underwent successful percutaneous intervention of the proper coronary artery. Physicians and sufferers should be aware of the clinical penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a part of endothelial dysfunction has been proposed, which can contribute to irregular vessel reactivity.
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Moreover, testosterone has been used within the remedy of decreased muscle mass and bone density as well as anemia. The position testosterone might play in the improvement of cardiovascular disease has increasingly become the topic of present interest . Anabolic androgenic steroid use has elevated over the previous decade, despite its potential for opposed results. They proceed for use by Olympic level athletes, and have even unfold to high school degree athletes, noncompetitive bodybuilders and recreational athletes (Sullivan et al 1998; Dhar et al 2007).
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Case Report
However, testosterone in physiologic doses could even be beneficial in patients with angina , have larger ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood flow in males with established coronary artery illness . Therefore, an interaction of endogenous factors of the patient’s danger profile in addition to the testosterone dosing may be problems with whether or not adverse occasions happen. Erythrocytosis has been reported as a potential effect of testosterone, which may be beneficial in patients with anemia. The biggest danger of erythrocytosis happens with injectable forms of testosterone compared with transdermal preparations, particularly in supraphysiologic doses. An increase of as much as 44% of the baseline hematocrit has been reported .
Discussion And Review Of The Literature
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Unfortunately, the information on using excessive dose anabolic steroids in humans are primarily provided as case reviews or small research that lack enough control groups. In addition, the information obtainable within the literature does not account for the steroid kind or dose, as neither could also be identified. Patients also could also be taking concomitant stimulants, corresponding to ephedra, which may confound data and the potential for opposed events. It is probably going that the frequency of cardiac events is underreported in the medical literature. Supraphysiologic doses of anabolic-androgenic steroids , which include more than 30 pure and synthetic derivatives of testosterone, might cause a wide spectrum of medical sequalae.
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