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Patients additionally could also be taking concomitant stimulants, such as ephedra, which may confound information and the potential for antagonistic occasions. It is likely that the frequency of cardiac events is underreported in the medical literature. Moreover, testosterone has been used in the therapy of decreased muscle mass and bone density in addition to anemia. The position testosterone could play in the development of cardiovascular disease has increasingly become the topic of present curiosity . Supraphysiologic doses of anabolic-androgenic steroids , which embrace more than 30 natural and synthetic derivatives of testosterone, could trigger a large spectrum of clinical sequalae. Supplemental or physiologic doses of testosterone have observed expanded use in medical apply lately. Other widespread potential opposed results embody infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .
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We report a case of an acute ST-segment elevation myocardial infarction in a affected person with conventional cardiac threat elements utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person also had polycythemia, likely secondary to high-dose testosterone. The affected person underwent profitable percutaneous intervention of the best coronary artery. Physicians and sufferers should be aware of the medical consequences of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a element of endothelial dysfunction has been proposed, which may contribute to irregular vessel reactivity.
However, testosterone in physiologic doses may even be helpful in sufferers with angina , have larger ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood move in males with established coronary artery illness . Therefore, an interplay of endogenous factors cam sex live of the patient’s danger profile as nicely as the testosterone dosing could additionally be issues of whether opposed events occur. Erythrocytosis has been reported as a possible impact of testosterone, which could be helpful in patients with anemia.
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